Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans
By integrating remote homology detection, AlphaFold structural modeling, and functional genetics, this study reveals that Scm3/HJURP orthologs are universally conserved across metazoans despite rapid sequence divergence, overturning the previous belief that they were absent in insects, nematodes, and many vertebrates.